Jose Lopez doubled in the go-ahead run in the seventh and homered, Kenji Johjima and Richie Sexson also went deep, and the Seattle Mariners defeated the San Diego Padres 7-4 on Friday night.

Mike Piazza and Josh Bard homered for the Padres, who lost for only the fourth time in 18 games in May.

Facing Padres reliever Scott Cassidy (3-2), Yuniesky Betancourt singled, stole second and went to third on catcher Bard's throwing error. With the infield in, Ichiro Suzuki got aboard on shortstop Khalil Greene's fielding error.

Lopez then doubled in Betancourt for his second RBI to snap a 3-3 tie. Alan Embree came in and gave up an RBI single to Raul Ibanez to score Suzuki.

In the eighth, Jeremy Reed hit an RBI triple for Seattle, then scored on left fielder Eric Young's error.

Rafael Soriano (1-1) got his first victory since Aug. 29, 2003, giving up one run on one hit and one walk, in two innings of relief. J.J. Putz pitched the ninth for Seattle.

Returning to Seattle after suffering a three-game sweep in Oakland, the Mariners went ahead 1-0 in the second on Johjima's off Chris Young. They made it 3-0 in the third on solo homers by Lopez and Sexson against Young, who now has given up 10 homers this season.

Piazza homered off Jarrod Washburn, his fifth of the season, in the fourth, but Washburn escaped possible disaster in the fifth, giving up only one run.

Suzuki, the five-time Gold Glove right fielder, made a perfect throw to catcher Johjima on the fly to end the fifth by getting Josh Barfield at the plate. Barfield ran over Johjima, but the catcher held onto the ball.

The double play in the fifth came after Vinny Castilla singled, Barfield doubled him to third and Bard had a sacrifice fly for San Diego's second run.

The Padres tied the score at 3 in the seventh when Bard homered off Soriano, who replaced Washburn in the top of the inning.

Bard added an RBI double in the ninth to make it 7-4 and finished 2-for-3 with three RBIs.

Washburn now hasn't won in four starts in May since his last victory on April 26, but the veteran left-hander pitched well enough to win. In six innings, he gave up two runs on five hits and two walks, with three strikeouts.

The 6-foot-10 Young also went six innings, allowing three runs on three hits, all homers, and two walks, with five strikeouts.

Notes: Piazza hit his 402nd career homer and his first at Safeco Field, the 37th major league ballpark he has homered in . ... Suzuki singled in the first to increase his season-high hitting streak to 13 games. ... Safeco's retractable roof was closed for the third time this season. ... Carl Everett of the Mariners stole his first base of 2006. ... The Mariners have hit three or more homers three times this season.